Retinoic-acid-induced apoptosis in leukemia cells.
Trends Mol Med
; 10(10): 508-15, 2004 Oct.
Article
em En
| MEDLINE
| ID: mdl-15464451
ABSTRACT
Retinoic acid (RA) cures more than 75% of patients with acute promyelocytic leukemia (APL). Here, we review the various anti-cancer activities of retinoids and rexinoids, alone and in combination with other drugs, with emphasis on the RA-dependent induction of a cancer-cell-selective apoptosis signaling pathway to which multiple anti-cancer signals converge. These findings identify the TRAIL (tumor-necrosis-factor-related apoptosis-inducing ligand) pathway as a central cell-autonomous anti-cancer weapon that can act independently of the immune system.
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Base de dados:
MEDLINE
Assunto principal:
Retinoides
/
Leucemia Promielocítica Aguda
/
Apoptose
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article