Quinolinic acid induces NMDA receptor-mediated lipid peroxidation in rat brain microvessels.
Redox Rep
; 9(4): 229-33, 2004.
Article
em En
| MEDLINE
| ID: mdl-15479567
ABSTRACT
Quinolinic acid increased the generation of lipid peroxidation products by isolated rat brain microvessels in vitro. The effect was inhibited both by a specific NMDA receptor antagonist D-2-amino-5-phosphonovaleric acid and by reduced glutathione (GSH). Furthermore, quinolinic acid displaced specific binding of [(3)H]-L-glutamate by cerebral microvessel membranes, particularly in the presence of NMDA receptor co-agonist (glycine) and modulator (spermidine). We conclude that quinolinic acid can cause potentially cytotoxic lipid peroxidation in brain microvessels via an NMDA receptor mediated mechanism.
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Base de dados:
MEDLINE
Assunto principal:
Peroxidação de Lipídeos
/
Circulação Cerebrovascular
/
Receptores de N-Metil-D-Aspartato
/
Microcirculação
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article