Pharmacokinetic data in the evaluation of the safety of food and color additives.
Regul Toxicol Pharmacol
; 15(1): 62-72, 1992 Feb.
Article
em En
| MEDLINE
| ID: mdl-1553413
ABSTRACT
Safety evaluation of food and color additives intended for human use is usually based on toxicity data obtained from animal studies; human data are rarely available. The extrapolation of animal data to humans is often controversial. The important role that pharmacokinetic data could play in the safety evaluation of food and color additives is now widely recognized. This paper reviews the current scientific knowledge concerning the application of properly designed pharmacokinetic studies to the evaluation of the safety of food and color additives. In principle, pharmacokinetic data can be useful not only in designing, interpreting, and extrapolating animal toxicity studies to humans, but also in providing insight into the mechanisms of toxicity. Examples of such applications are provided.
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Base de dados:
MEDLINE
Assunto principal:
Aditivos Alimentares
/
Corantes de Alimentos
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article