Simplification and improvement of height-based azithromycin treatment for paediatric trachoma.
Trans R Soc Trop Med Hyg
; 99(1): 6-12, 2005 Jan.
Article
em En
| MEDLINE
| ID: mdl-15550255
ABSTRACT
Recent data showing that azithromycin is safe at higher dosages than previously documented provide an opportunity to explore several important improvements in the efficiency and effectiveness of height-based treatment of paediatric trachoma. The purpose of this study is to examine the feasibility of a single standardised schedule for application in any trachoma-endemic region. Data for 60813 children from Asia, North and sub-Saharan Africa were analysed. A height schedule maximizing the number of children receiving treatment of 20-40 mg/kg, a conservative estimate of the safe and effective treatment range for paediatric trachoma, was developed. Using the standardised schedule, 97.7% of children aged 6 to 59 months receiving oral suspension and 96.7% of children aged 60 months to 15 years receiving tablets would have received treatment within a dosage range of 20-40 mg/kg. Less than 1% of all children would have received treatment less than 20 mg/kg. These findings suggest that the schedule presented in this paper is likely to yield safe and effective treatment for a broad range of populations vulnerable to trachoma while substantially improving the efficiency of height-based treatment.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Estatura
/
Tracoma
/
Azitromicina
/
Antibacterianos
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article