An open trial of olanzapine in anorexia nervosa.
J Clin Psychiatry
; 65(11): 1480-2, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15554759
ABSTRACT
BACKGROUND:
Recent reports raise the possibility that olanzapine can assist weight gain and improve behavioral symptoms during refeeding in anorexia nervosa.METHOD:
Seventeen DSM-IV anorexia nervosa subjects hospitalized between May 1999 and October 2000 were enrolled in open-label treatment with olanzapine for up to 6 weeks. Baseline weight and symptoms were compared to patients' status at the end of treatment.RESULTS:
Olanzapine administration was associated with a significant reduction in depression, anxiety, and core eating disorder symptoms, and a significant increase in weight. A comparison with our historical data suggests that subjects in this study had a significantly greater decrease in depression.CONCLUSION:
These data lend support to the possibility that olanzapine may be useful in treating anorexia nervosa. However, a controlled trial is necessary to demonstrate that olanzapine is efficacious.
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Base de dados:
MEDLINE
Assunto principal:
Antipsicóticos
/
Benzodiazepinas
/
Anorexia Nervosa
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article