Prevalence of HCV coinfection in HIV-infected individuals in Nigeria and characterization of HCV genotypes.
J Clin Virol
; 31 Suppl 1: S3-6, 2004 Dec.
Article
em En
| MEDLINE
| ID: mdl-15567088
ABSTRACT
BACKGROUND:
Coinfection with hepatitis C virus (HCV) in individuals infected with HIV is associated with a higher incidence of liver injury, hepatic decompensation, and decreased survival time than that seen in an HIV-monoinfected population. While prevalence studies on HIV/HCV coinfection have been performed in the U.S. and in some European countries, little is known about coinfection rates in Africa.DESIGN:
Retrospectively collected specimens from 146 confirmed HIV-positive individuals in Nigeria who had access to antiretroviral therapy (ART) were tested for HCV RNA, using the VERSANT HCV RNA qualitative assay (TMA), and, if HCV RNA-positive, for HCV genotype using the VERSANT HCV genotype assay (LiPA).RESULTS:
Twelve out of the 146 individuals tested (8.2%) were HCV positive. Nine of the 12 HCV-positive individuals were infected with HCV genotype 1 (five 1a, three 1b, one non-subtypable) and three were infected with HCV genotype 2 (all non-subtypable). Coinfected individuals were more likely to be male, older, and have lower CD4+ cell counts than HIV-monoinfected individuals, although none of the differences reached statistical significance.CONCLUSION:
The results highlight the potential public health impact of HCV infection in Nigeria, where anti-HCV testing is generally not performed in HIV-infected populations or in most blood transfusion centers.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
RNA Viral
/
Infecções por HIV
/
Hepatite C
/
Hepacivirus
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article