Ubiquitin: structures, functions, mechanisms.
Biochim Biophys Acta
; 1695(1-3): 55-72, 2004 Nov 29.
Article
em En
| MEDLINE
| ID: mdl-15571809
ABSTRACT
Ubiquitin is the founding member of a family of structurally conserved proteins that regulate a host of processes in eukaryotic cells. Ubiquitin and its relatives carry out their functions through covalent attachment to other cellular proteins, thereby changing the stability, localization, or activity of the target protein. This article reviews the basic biochemistry of these protein conjugation reactions, focusing on ubiquitin itself and emphasizing recent insights into mechanism and specificity.
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Base de dados:
MEDLINE
Assunto principal:
Ubiquitina
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article