Properties of metabolic networks: structure versus function.
Biophys J
; 88(1): L07-9, 2005 Jan.
Article
em En
| MEDLINE
| ID: mdl-15574705
ABSTRACT
Biological data from high-throughput technologies describing the network components (genes, proteins, metabolites) and their associated interactions have driven the reconstruction and study of structural (topological) properties of large-scale biological networks. In this article, we address the relation of the functional and structural properties by using extensively experimentally validated genome-scale metabolic network models to compute observable functional states of a microorganism and compare the "structure versus function" attributes of metabolic networks. It is observed that, functionally speaking, the essentiality of reactions in a node is not correlated with node connectivity as structural analyses of other biological networks have suggested. These findings are illustrated with the analysis of the genome-scale biochemical networks of three species with distinct modes of metabolism. These results also suggest fundamental differences among different biological networks arising out of their representation and functional constraints.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biologia
/
Fenômenos Fisiológicos Celulares
/
Metabolismo
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article