Bilateral hand transplantation: bone healing under immunosuppression with tacrolimus, mycophenolate mofetil, and prednisolone.
J Hand Surg Am
; 29(6): 1020-7, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15576210
ABSTRACT
PURPOSE:
Little is known about bone healing after composite tissue transplantation that requires pharmacologic immunosuppression. Bone integration and callus development were assessed in bilateral hand transplantation.METHODS:
In this study the course of callus development and callus maturation were assessed by color Doppler sonography and radiography in a double hand transplant and compared with forearm replantation.RESULTS:
After hand transplantation, ingrowth of small vessels at the bone junction was observed at week 3, calcified callus became visible at month 4, and bone union was completed at month 11. A similar time course of bone integration was observed after replantation. Plating offered sufficient stability. A recipient periostal flap is thought to have improved blood supply and favored development and induction of callus.CONCLUSIONS:
Bone healing after hand transplantation under immunosuppression with tacrolimus, mycophenolate mofetil, and prednisolone is identical to that after forearm replantation.
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Base de dados:
MEDLINE
Assunto principal:
Reimplante
/
Traumatismos por Explosões
/
Prednisolona
/
Tacrolimo
/
Consolidação da Fratura
/
Transplante de Mão
/
Traumatismos do Antebraço
/
Traumatismos da Mão
/
Imunossupressores
/
Ácido Micofenólico
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article