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Predisposition to nevirapine hypersensitivity associated with HLA-DRB1*0101 and abrogated by low CD4 T-cell counts.
Martin, Annalise M; Nolan, David; James, Ian; Cameron, Paul; Keller, Jean; Moore, Corey; Phillips, Elizabeth; Christiansen, Frank T; Mallal, Simon.
Afiliação
  • Martin AM; Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, Western Australia.
AIDS ; 19(1): 97-9, 2005 Jan 03.
Article em En | MEDLINE | ID: mdl-15627041
Genetic (human leukocyte antigen), disease-related and demographic risk factors for nevirapine reactions were examined in a nevirapine-exposed cohort. Cases involving combinations of hepatitis, fever or rash were associated with an interaction between HLA-DRB1*0101 and the percentage of CD4, whereas no associations were detected for isolated rash. These data suggest that HLA-DRB1*0101 and the CD4 status may determine susceptibility to nevirapine hypersensitivity, consistent with a CD4 T-cell-dependent immune response to nevirapine-specific antigens.
Assuntos
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Base de dados: MEDLINE Assunto principal: Antígenos HLA-A / Inibidores da Transcriptase Reversa / Nevirapina / Predisposição Genética para Doença / Hipersensibilidade a Drogas Idioma: En Ano de publicação: 2005 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Antígenos HLA-A / Inibidores da Transcriptase Reversa / Nevirapina / Predisposição Genética para Doença / Hipersensibilidade a Drogas Idioma: En Ano de publicação: 2005 Tipo de documento: Article