Preparation of 8-(arylsulfanyl)adenines with diazonium salts under mild, aerobic conditions.
J Org Chem
; 70(2): 717-20, 2005 Jan 21.
Article
em En
| MEDLINE
| ID: mdl-15651828
ABSTRACT
8-(Arylsulfanyl)adenines 11 were prepared in up to 75% yield by reacting the 8-thionoadenine 6 (acetic acid 3-(6-amino-8-thioxo-7,8-dihydropurin-9-yl)propyl ester) with benzenediazonium tetrafluoroborates in DMSO. Benzenediazonium ions carrying an electron-withdrawing substituent gave the highest yields. The reaction proceeded smoothly at room temperature without any base and could be performed under air atmosphere. The extremely mild conditions are compatible with a wide range of functional groups.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Adenina
/
Compostos de Diazônio
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article