Evaluation of the inheritance of the complex vertebral malformation syndrome by breeding studies.
Acta Vet Scand
; 45(3-4): 133-7, 2004.
Article
em En
| MEDLINE
| ID: mdl-15663073
ABSTRACT
To investigate the congenital complex vertebral malformation syndrome (CVM) in Holstein calves, two breeding studies were performed including 262 and 363 cows, respectively. Cows were selected from the Danish Cattle Database based on pedigree and insemination records. Selected cows were progeny of sires with an established heterozygous CVM genotype and pregnant after insemination with semen from another sire with heterozygous CVM genotype. Following calving the breeders should state, if the calf was normal and was requested to submit dead calves for necropsy. In both studies, significantly fewer CVM affected calves than expected were obtained; a finding probably reflecting extensive intrauterine mortality in CVM affected foetuses. The findings illustrate increased intrauterine mortality as a major potential bias in observational studies of inherited disorders.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anormalidades Múltiplas
/
Bovinos
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Doenças dos Bovinos
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Vértebras Cervicais
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article