Experimental charge density of a potential DHO synthetase inhibitor: dimethyl-trans-2-oxohexahydro-pyrimidine-4,6-dicarboxylate.
Org Biomol Chem
; 3(3): 441-7, 2005 Feb 07.
Article
em En
| MEDLINE
| ID: mdl-15678181
ABSTRACT
The experimental charge density distribution of dimethyl-trans-2-oxohexahydro-pyrimidine-4,6-dicarboxylate 1 has been determined using single-crystal X-ray diffraction data measured at 100 K, in terms of the rigid-pseudoatom formalism. Multipole refinement converged at R(F) = 0.034 for 7283 reflections with I > 3 sigma (I) and sin theta/lambda < or = 1.13 A(-1). Covalent and hydrogen bonding interactions are analyzed using a topological analysis of the Laplacian of the charge density. The experimentally derived electrostatic potential mapped onto the reactive surface of the molecule reveals the potential binding sites of 1.
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Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Ácidos Carboxílicos
/
Inibidores Enzimáticos
/
Modelos Químicos
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article