Cryptic 5' MLL gene insertion in an X-chromosome in acute myeloblastic leukemia.
Cancer Genet Cytogenet
; 157(2): 178-80, 2005 Mar.
Article
em En
| MEDLINE
| ID: mdl-15721643
ABSTRACT
Band 11q23 is known to be involved in translocations and insertions with a variety of partner chromosomes. They lead to MLL rearrangement, resulting in fusion with numerous genes. We report here on a 43-year-old man presenting with asthenia and pancytopenia who was diagnosed with acute myeloblastic leukemia FAB-M5. Conventional cytogenetic techniques showed a del(11)(q21). Using a specific probe for fluorescent in situ hybridization, the MLL gene was found to be disrupted, with the 5' region being inserted into the X-chromosome (around bands q24 approximately q25), as confirmed by whole X-chromosome painting. The accumulating data on acute myeloblastic leukemia demonstrate that the 5'-MLL insertion in an X-chromosome is a rare but recurrent abnormality associated with leukemia, not only in infants, but also in adults.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Translocação Genética
/
Cromossomos Humanos Par 11
/
Proto-Oncogenes
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Leucemia Mieloide Aguda
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Cromossomos Humanos X
/
Proteínas de Ligação a DNA
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article