Elevated serum beta-defensins concentrations in patients with lung cancer.
Anticancer Res
; 24(6): 4051-7, 2004.
Article
em En
| MEDLINE
| ID: mdl-15736451
BACKGROUND: Beta-defensins (HBDs) are expressed in lung epithelial cells and act as antimicrobial agents. Most lung cancers that originate from pulmonary epithelial cells may produce HBDs. MATERIALS AND METHODS: We measured serum HBD-1 and HBD-2 levels in healthy subjects (HS), patients with lung cancer and patients with pneumonia by radioimmunoassay. RESULTS: Serum HBD-1 levels were higher in patients with lung cancer than HS and patients with pneumonia. Serum HBD-2 levels were higher in patients with lung cancer than HS. When cut-off values for positive HBD-1 were set at mean + 2SD of HS, the sensitivity and specificity of HBD-1 for the whole group of patients with lung cancer were 76.4 and 94.0%, respectively, and the proportion of patients with HBD-1-positive lung cancer and clinical stage I was 69.2%. CONCLUSION: Serum HBDs levels were high in patients with lung cancer and the serum HBD-1 level could be used as an auxiliary diagnostic tool for lung cancer.
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Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
/
Beta-Defensinas
/
Neoplasias Pulmonares
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article