Little effects of low dosage of levomepromazine on plasma risperidone levels.
Pharmacopsychiatry
; 38(2): 98-100, 2005 Mar.
Article
em En
| MEDLINE
| ID: mdl-15744635
ABSTRACT
In the present study, we investigated the effects of levomepromazine on plasma risperidone concentrations in a steady state. Twenty patients taking risperidone at a stable dose for more than 2 weeks who were considered to require levomepromazine coadministration were selected. The scores of excitement in BPRS significantly decreased 2 weeks after the coadministration of levomepromazine. Plasma risperidone concentrations and the ratio of risperidone and 9-hydroxyrisperidone (risperidone/9-hydroxyrisperidone) did not change between before and 2 weeks after the coadministration of levomepromazine. The extrapyramidal symptoms were not worsened by the coadministration of levomepromazine. These results suggest that a low dosage of levomepromazine, use as a sedative adjuvant to risperidone treatment, have no statistically significant effect on the trough plasma concentrations of risperidone.
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Base de dados:
MEDLINE
Assunto principal:
Transtornos Psicóticos
/
Antipsicóticos
/
Risperidona
/
Metotrimeprazina
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article