The relA homolog of Mycobacterium smegmatis affects cell appearance, viability, and gene expression.
J Bacteriol
; 187(7): 2439-47, 2005 Apr.
Article
em En
| MEDLINE
| ID: mdl-15774887
ABSTRACT
The modification of metabolic pathways to allow for a dormant lifestyle appears to be an important feature for the survival of pathogenic bacteria within their host. One regulatory mechanism for persistent Mycobacterium tuberculosis infections is the stringent response. In this study, we analyze the stringent response of a nonpathogenic, saprophytic mycobacterial species, Mycobacterium smegmatis. The use of M. smegmatis as a tool for studying the mycobacterial stringent response was demonstrated by measuring the expression of two M. tuberculosis genes, hspX and eis, in M. smegmatis in the presence and absence of rel(Msm). The stringent response plays a role in M. smegmatis cellular and colony formation that is suggestive of changes in the bacterial cell wall structure.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Mycobacterium smegmatis
/
Genes Bacterianos
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article