Effect of systemic lidocaine on visceral and somatic nociception in conscious horses.
Equine Vet J
; 37(2): 122-7, 2005 Mar.
Article
em En
| MEDLINE
| ID: mdl-15779623
ABSTRACT
REASONS FOR PERFORMING STUDY Commonly used analgesics (nonsteroidal anti-inflammatory agents, opioids and alpha2-agonists) have unwanted side effects. An effective alternative with minimal adverse effects would benefit clinical equine pain management. OBJECTIVES:
To compare the effect of lidocaine or saline on duodenal and rectal distension threshold pressure and somatic thermal threshold in conscious mature horses.HYPOTHESIS:
Systemically administered lidocaine would increase somatic and visceral nociceptive thresholds.METHODS:
Lidocaine (2 mg/kg bwt bolus followed by 50 microg/kg bwt/min for 2 h) or saline was administered to 6 horses each carrying a permanently implanted gastric cannula, in a randomised, blinded cross-over design. Thermal threshold was measured using a probe containing a heater element placed over the withers which supplied heat until the horse responded. A barostatically controlled intraduodenal balloon was distended until a discomfort response was obtained. A rectal balloon was inflated until extruded or signs of discomfort noted.RESULTS:
Thermal threshold was increased significantly 30 and 90 mins after the start of lidocaine infusion. There was no change in duodenal distension pressure and a small but clinically insignificant change in colorectal distension pressure in the lidocaine group.CONCLUSIONS:
At the dose used, systemically administered lidocaine produced thermal antinociception but minimal changes in visceral nociception. POTENTIAL RELEVANCE At these doses, lidocaine may play a role in somatic analgesia in horses.
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Base de dados:
MEDLINE
Assunto principal:
Dor
/
Doenças dos Cavalos
/
Analgesia
/
Anestésicos Locais
/
Lidocaína
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article