3-Substituted imidazo[1,2-d][1,2,4]-thiadiazoles: a novel class of factor XIIIa inhibitors.
J Med Chem
; 48(7): 2266-9, 2005 Apr 07.
Article
em En
| MEDLINE
| ID: mdl-15801818
ABSTRACT
A new class of selective FXIIIa inhibitors with a bicyclic [1,2,4]-thiadiazole pharmacophore is described. At 160 muM, compound 8 caused 50% reduction in fibrin gamma-chain cross-linking and suppressed the polymerization of alpha chains in platelet-depleted human plasma clots. Fibrinolysis rates in response to tissue plasminogen activator were directly proportional to the concentration of 8 in plasma at the time of clotting.
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Base de dados:
MEDLINE
Assunto principal:
Tiadiazóis
/
Fator XIII
/
Fibrinolíticos
/
Imidazóis
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article