Paraneoplastic recurrent multifocal encephalitis presenting with epilepsia partialis continua.
J Neurooncol
; 72(1): 63-6, 2005 Mar.
Article
em En
| MEDLINE
| ID: mdl-15803377
ABSTRACT
We report a 46-year-old female patient in whom epilepsia partialis continua was the initial presentation of small cell lung cancer. Magnetic resonance imaging revealed multiple, bilateral cortical lesions, which were originally misinterpreted and treated as brain metastases. Intracranial lesions and neurological symptoms remitted after corticosteroids, chemotherapy, and radiotherapy. After an asymptomatic interval of 18 months, neurological symptoms recurred with more extensive involvement of completely different parts of the central nervous system (limbic, brainstem and cerebellar structures) without any evidence of tumor recurrence. Both episodes showed a distinctive response to immunosuppressive therapy. The diagnostic challenges of the highly variable clinical presentations and therapeutic approaches to paraneoplastic multifocal encephalitis are discussed with relevant literature review.
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Base de dados:
MEDLINE
Assunto principal:
Epilepsia Parcial Contínua
/
Carcinoma de Células Pequenas
/
Síndromes Paraneoplásicas do Sistema Nervoso
/
Encefalite
/
Neoplasias Pulmonares
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article