A conserved HLA B13-restricted cytotoxic T lymphocyte epitope in Nef is a dominant epitope in HLA B13-positive HIV-1-infected patients.
AIDS
; 19(7): 734-5, 2005 Apr 29.
Article
em En
| MEDLINE
| ID: mdl-15821402
ABSTRACT
We report on the first HLA B13-restricted minimal cytotoxic T lymphocyte (CTL) epitope RQDILDLWI (RI9, amino acids 106-114 in HIV-1 Nef). In most patients the frequency of RI9-specific CTL exceeded the number of CTL against other epitopes, indicating that RI9 is a dominant epitope in HLA B13-positive patients. Targeting this conserved Nef epitope may be an important factor for the published association of HLA B13 with a favourable course of HIV-1 infection.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos T Citotóxicos
/
Antígenos HLA-B
/
Produtos do Gene nef
/
Infecções por HIV
/
HIV-1
/
Epitopos de Linfócito T
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article