Highly functionalized cyclopentanes from meso bicyclic hydrazines. A rapid access to mannosidase inhibitors.
J Org Chem
; 70(8): 3316-7, 2005 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-15823005
ABSTRACT
A simple diastereoselective access to amino- and hydrazinocyclopentitols is described. The key step involves a cationic rearrangement of a meso bicyclic hydrazine, followed by two successive stereoselective hydroxylations. Both racemic compounds are micromolar alpha-mannosidase (Jack bean) inhibitors.
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Base de dados:
MEDLINE
Assunto principal:
Ciclopentanos
/
Alfa-Manosidase
/
Inibidores Enzimáticos
/
Hidrazinas
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article