Differential expression of L-selectin ligand in the endometrium during the menstrual cycle.
Fertil Steril
; 83 Suppl 1: 1297-302, 2005 Apr.
Article
em En
| MEDLINE
| ID: mdl-15831305
ABSTRACT
OBJECTIVE:
To evaluate the expression of L-selectin ligand in the endometrium during the menstrual cycle.DESIGN:
Retrospective study.SETTING:
University teaching hospital. PATIENT(S) Endometrial samples from regularly cycling women. INTERVENTION(S) Tissue microarray and immunohistochemical staining were performed using L-selectin ligand monoclonal antibody (MECA-79). MAIN OUTCOME MEASURE(S) Expression of L-selectin ligand in the various phases of menstrual cycle was measured by a semiquantitative analysis (HSCORE) for the intensity of immunohistochemical reactivity. RESULT(S) In the luminal epithelium, there were significant differences in L-selectin ligand expression during the proliferative, interval, early secretory, and midsecretory phases. The expression of L-selectin ligand was greatest from the periovulatory interval through midsecretory phase. In the glandular epithelium, the expression of L-selectin ligand was greatest in midsecretory phase with significant differences between proliferative phase and the midsecretory phase and between the interval phase and the midsecretory phase. CONCLUSION(S) Increased expression of L-selectin ligand in the human endometrium during the early and midsecretory phases of the menstrual cycle may be related to the process of implantation.
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Base de dados:
MEDLINE
Assunto principal:
Selectina L
/
Endométrio
/
Ciclo Menstrual
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article