TEL/AML1 and immunoreceptor gene rearrangements-which comes first?
Leuk Res
; 29(6): 633-9, 2005 Jun.
Article
em En
| MEDLINE
| ID: mdl-15863202
ABSTRACT
TEL/AML1 fusion gene is present in 20-25% of childhood acute lymphoblastic leukaemias. In order to unravel at which stage of B-cell precursor development the fusion is originated, we analysed frequency and pattern of immunoreceptor (immunoglobulin and T-cell receptor) gene rearrangements in 47 TEL/AML1-positive and 43 TEL/AML1-negative cases of the same CD10+ immunophenotype. Moreover, we compared corresponding immunoreceptor gene rearrangements in 11 cases of TEL/AML1-positive leukaemia at diagnosis and relapse. More mature immunogenotype of TEL/AML1-positive cases and changes in 37% of rearrangements between diagnosis and relapse suggest that in most cases the TEL/AML1 fusion is formed during immunoreceptor gene rearrangement process.
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Base de dados:
MEDLINE
Assunto principal:
Receptores Imunológicos
/
Proteínas de Fusão Oncogênica
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article