Plucked human hair as a tissue in which to assess pharmacodynamic end points during drug development studies.
Br J Cancer
; 92(10): 1837-41, 2005 May 23.
Article
em En
| MEDLINE
| ID: mdl-15886708
ABSTRACT
We have demonstrated the feasibility of detecting and quantifying six cell-cycle-related nuclear markers (Ki67, pRb, p27, phospho-p27 (phosphorylated p27), phospho-pRb (phosphorylated pRb), phospho-HH3 (phosphorylated histone H3)) in plucked human scalp and eyebrow hair. Estimates of the proportion of plucked hairs that are lost or damaged during processing plus the intra- and intersubject variability of each nuclear marker with these techniques are provided to inform sizing decisions for intervention studies with drugs potentially impacting on these markers in the future.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
/
Ciclo Celular
/
Cabelo
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article