The research on biotransformation of praziquantel.
Acta Pol Pharm
; 61 Suppl: 75-8, 2004 Dec.
Article
em En
| MEDLINE
| ID: mdl-15909947
ABSTRACT
Praziquantel (PZQ), a broad spectrum antihelmintic drug, is extensively metabolized in the liver, yielding mainly monohydroxylated and dihydroxylated phase-I-metabolites. However, the exact chemical structures of the most metabolites are still unknown. In the presented research, three types of PZQ biotransformations were performed biotransformation with the whole cells of Saccharomyces cerevisiae, with cytochrome c from Saccharomyces cerevisiae and with microsomes isolated from Saccharomyces cerevisiae. To describe the obtained metabolites TLC, RP-TLC, and HPLC were used.
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Base de dados:
MEDLINE
Assunto principal:
Praziquantel
/
Antiplatelmínticos
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article