Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid.
Bioorg Med Chem Lett
; 15(11): 2812-8, 2005 Jun 02.
Article
em En
| MEDLINE
| ID: mdl-15911260
ABSTRACT
A novel series of non-nucleoside HCV NS5B polymerase inhibitors was prepared from a (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid template. Solution and solid phase analog synthesis focused on the northern region of the template combined with structure based design led to the discovery of several potent and orally bioavailable lead compounds.
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Base de dados:
MEDLINE
Assunto principal:
Acrilatos
/
RNA Polimerase Dependente de RNA
/
Proteínas não Estruturais Virais
/
Inibidores Enzimáticos
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article