High cumulative insulin exposure: a risk factor of atherosclerosis in type 1 diabetes?
Atherosclerosis
; 181(1): 185-92, 2005 Jul.
Article
em En
| MEDLINE
| ID: mdl-15939071
ABSTRACT
BACKGROUND:
Since insulin therapy might have an atherogenic effect, we studied the relationship between cumulative insulin dose and atherosclerosis in type 1 diabetes. We have focused on patients with type 1 diabetes instead of type 2 diabetes to minimise the effect of insulin resistance as a potential confounder.METHODS:
An observational study was performed in 215 subjects with type 1 diabetes treated with multiple insulin injection therapy. Atherosclerosis was assessed by measurement of carotid intima-media thickness (CIMT).RESULTS:
The cumulative dose of regular insulin showed a positive and significant relation with CIMT increase of 21 microm in CIMT per S.D. of insulin use (95% CI 8-35 adjusted for gender and age), which remained unchanged after adjustment for duration of diabetes, HbA1c, BMI, pulse pressure, physical activity and carotid lumen diameter. A similar relation was found for intermediate-acting insulin 15.5 microm per S.D. (2-29), which was no longer present after further adjustment.CONCLUSIONS:
These findings provide evidence that a high cumulative dose of regular insulin is a risk factor for atherosclerosis.
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Base de dados:
MEDLINE
Assunto principal:
Arteriosclerose
/
Diabetes Mellitus Tipo 1
/
Hipoglicemiantes
/
Insulina
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article