The Belgrade childhood diabetes study: a multivariate analysis of risk determinants for diabetes.
Eur J Public Health
; 15(2): 117-22, 2005 Apr.
Article
em En
| MEDLINE
| ID: mdl-15941756
ABSTRACT
BACKGROUND:
The aim of this study was to evaluate some hypotheses about factors related to the development of type 1 diabetes mellitus.METHODS:
A case-control study was conducted in Belgrade during the period 1994-1997. A total of 105 recently onset diabetic and 210 control children, individually matched by age (+/-1 year), sex and place of residence, were included in the study.RESULTS:
According to multivariate regression analysis, the following factors were related to type 1 diabetes stressful events and symptoms of psychological dysfunction during the 12 months preceding the onset of the disease [odds ratio (OR) 3.48, 95% confidence interval (CI) 2.15-5.65; and OR 2.15, 95% CI 1.33-3.48], irregular vaccination (OR 16.98, 95% CI 1.38-208.92), infection during 6 months preceding the onset of the disease (OR 4.23, 95% CI 1.95-9.17), higher education of father (OR 1.50, 95% CI 1.05-2.14), mother's consumption of nitrosoamines-rich food during pregnancy (OR 4.33, 95% CI 1.95-9.61), alcohol consumption by father (OR 3.80, 95% CI 1.64-8.78), insulin-dependent and non-insulin-dependent diabetes mellitus in three generations of children's relatives (OR 20.04, 95% CI 4.73-84.81; and OR 5.52, 95% CI 2.45-12.46), and use of ultrasound diagnostic techniques during pregnancy (OR 0.42, 95% CI 0.17-1.00).CONCLUSIONS:
Among non-genetic factors, those affecting the child during pregnancy are especially important because of their preventability.
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Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 1
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article