The transcription factor PLA-1/SKN-1A is expressed in human placenta and regulates the placental lactogen-3 gene expression.
Placenta
; 27(4-5): 357-66, 2006.
Article
em En
| MEDLINE
| ID: mdl-16005513
ABSTRACT
Here we report the selective expression of two POU transcription factor genes, PLA-1 and OCT-1, in human placenta and choriocarcinoma cell lines JAR, JEG-3 and BeWo. Pla-1 protein binds to a POU-consensus DNA sequence in the human placental lactogen-3 (PL-3) promoter and it is capable of trans-activating its transcription up to 18-fold. Other tissue-specific or ubiquitous POU transcription factors such as Pit-1/GHF-1 or Oct-1 showed none or low levels of trans-activation of the PL-3 promoter. In addition, we identified an unique and highly charged region in the N-terminal portion of Pla-1 protein required for full trans-activation of the PL-3 promoter.
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Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Lactogênio Placentário
/
Fatores do Domínio POU
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article