Cerebral thrombotic complications in adolescent leukemia/lymphoma patients treated with L-asparaginase-containing chemotherapy.
Leuk Lymphoma
; 46(5): 729-35, 2005 May.
Article
em En
| MEDLINE
| ID: mdl-16019511
ABSTRACT
We described the cerebral thrombotic complications developed in 2 adolescent patients treated with L-asparaginase-containing regimens. For determining risk factors, we retrospectively analysed hemostatic markers in 19 pediatric patients with leukemia or lymphoma who were treated with either 1 of the 2 L-asparaginase-containing regimens; 11 were treated with VLP1 and the remaining 8 were treated with the VLAD protocol. The data indicated that low coagulation factors in association with increased plasma D-dimer levels during or post-L-asparaginase administration combined with fresh frozen plasma infusion might have activated coagulation processes in these patients. Careful management is required to prevent such episodes in patients with markedly decreased coagulation factors and increased D-dimer levels following L-asparaginase administration.
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Base de dados:
MEDLINE
Assunto principal:
Asparaginase
/
Linfoma não Hodgkin
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Trombose Intracraniana
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article