[Methiothepin-sensitive serotonin receptors are involved in postsynaptic mechanism of sensitization of Helix lucorum escape reaction].
Zh Vyssh Nerv Deiat Im I P Pavlova
; 55(3): 385-92, 2005.
Article
em Ru
| MEDLINE
| ID: mdl-16033241
Tetanic electric stimulation of Helix foot evokes sensitization of escape reaction. This behavioral sensitization and posttetanic potentiation (PTP) of acetylcholine-induced inward current (ACh-current) in command Helix neurons of escape behavior were similar. Antagonist of serotonin receptors methiothepin prevents the PTP of the ACh-current and behavioral sensitization. Serotonin disrupts the PTP of the ACh-current. It is suggested that the increase in cholinosensitivity of the command neurons with the involvement of methiothepin-sensitive serotonin receptors may be the cellular postsynaptic mechanism of behavioral sensitization of Helix escape reaction.
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Base de dados:
MEDLINE
Assunto principal:
Antagonistas da Serotonina
/
Receptores 5-HT1 de Serotonina
/
Reação de Fuga
/
Caracois Helix
/
Metiotepina
/
Neurônios
Idioma:
Ru
Ano de publicação:
2005
Tipo de documento:
Article