Adamantyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Bioorg Med Chem Lett
; 15(19): 4359-62, 2005 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-16039856
ABSTRACT
Adamantyl triazoles were identified as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). They are active both in in vitro and in in vivo pharmacodynamic models. The synthesis and structure-activity relationships of these inhibitors are presented.
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Base de dados:
MEDLINE
Assunto principal:
Triazóis
/
11-beta-Hidroxiesteroide Desidrogenase Tipo 1
/
Inibidores Enzimáticos
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article