Usefulness of serum endothelin levels in predicting death and myocardial infarction but not coronary progression in postmenopausal women with coronary disease (from the Women's Angiographic Vitamin and Estrogen [WAVE] study).
Am J Cardiol
; 96(3): 335-8, 2005 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-16054453
ABSTRACT
We performed a cohort study of 392 postmenopausal women who had coronary disease to assess whether baseline serum endothelin-1 level predicts angiographic disease progression, nonfatal myocardial infarction, or death. Angiographic progression was defined as the annualized change in minimal lumen diameter of all qualifying lesions for each patient. Twenty-nine patients died or had a myocardial infarction during follow-up. Each picogram per milliliter increase in endothelin-1 was associated with a 1.8-fold increased risk of death or myocardial infarction. After adjustment for potential confounders, endothelin-1 remained a predictor of clinical events but was not correlated with angiographic progression.
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Base de dados:
MEDLINE
Assunto principal:
Endotelina-1
/
Doença das Coronárias
/
Infarto do Miocárdio
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article