[Variable mechanisms of RNA-recombination].
Mol Biol (Mosk)
; 39(4): 618-32, 2005.
Article
em Ru
| MEDLINE
| ID: mdl-16083010
ABSTRACT
Recombination is widespread among RNA viruses but underlying mechanisms remain poorly understood. Until recently, replicative template switching was considered the only possible mechanism of RNA recombination but new evidence suggests that other variants of replicative mechanisms may also exist. In addition, nonreplicative recombination (i.e., joining of preexisting molecules) of genomes of RNA viruses is possible. Recombination is an efficient tool contributing to both variability and stability of the viral RNA genomes. Nonreplicative joining of RNA pieces in the form of trans-splicing is an important physiological mechanism in at least certain organisms. It is conceivable that RNA-recombination has contributed, and perhaps is still contributing, to the evolution of DNA genomes.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Recombinação Genética
/
RNA
Idioma:
Ru
Ano de publicação:
2005
Tipo de documento:
Article