The 2b protein as a minor structural component of PRRSV.
Virus Res
; 114(1-2): 177-81, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16095746
ABSTRACT
Porcine reproductive and respiratory syndrome virus (PRRSV) ORF2 contains an internal ORF that codes for a small non-glycosylated protein known as 2b. Previous work had identified the presence of a 10kDa 2b protein in virus-infected cells and the induction of an anti-2b response in PRRSV-infected pigs, as well as a possible association of 2b with the virion (, Virology 287183-191). In this study, we utilized two experimental approaches, including the use of a 2b peptide-specific monoclonal antibody, to demonstrate that the PRRSV 2b protein is an integral component of the PRRSV virion. This study suggests that 2b in PRRSV is similar to the E protein in EAV and forms a minor structural component of the virion.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vírion
/
Proteínas Estruturais Virais
/
Vírus da Síndrome Respiratória e Reprodutiva Suína
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article