A new class of high affinity thyromimetics containing a phenyl-naphthylene core.
Bioorg Med Chem Lett
; 15(20): 4579-84, 2005 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-16099653
ABSTRACT
High affinity thyromimetics containing a novel phenyl-naphthylene core are reported. The functionalized core is readily accessible via a Suzuki coupling protocol. Examples of this new class of TR ligands have sub-nanomolar binding affinities for the TRbeta receptor and low to modest selectivity for TRbeta. They also exhibit an SAR that diverges from other thyromimetics that are based on the diaryl ether core found in 3,5,3'-triiodothyronine.
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Base de dados:
MEDLINE
Assunto principal:
Hormônios Tireóideos
/
Receptores dos Hormônios Tireóideos
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Naftalenos
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article