Comparison of survival by allocation to medical therapy, surgery, or heart transplantation for ischemic advanced heart failure.
J Heart Lung Transplant
; 24(8): 983-9, 2005 Aug.
Article
em En
| MEDLINE
| ID: mdl-16102430
ABSTRACT
BACKGROUND:
To ascertain survival of ischemic advanced heart failure patients by treatment allocation, we examined the outcome of transplant assessment patients allocated to medical therapy, high-risk conventional surgery, or transplantation.METHODS:
Patients were identified from the Papworth transplant database and excluded if primary etiology was not ischemic. Grouping was undertaken according to treatment allocation at initial assessment, and analysis was performed by intention to treat. Survival was computed from the time of assessment and Cox regression used to stratify patients according risk with the Heart Failure Survival Score.RESULTS:
From May 1993 to September 2001, a total of 755 patients were admitted for transplant assessment, with 348 (46.1%) identified as having heart failure of ischemic origin. Variables required for calculation of the Heart Failure Survival Score was available in 273 patients (78.4%), and 20 patients (7.3%) were lost to follow-up. Of the remaining 253 patients, 89 (35.2%) were allocated to medical therapy, 32 (12.6%) to surgery, and 132 (52.2%) to transplantation. The relative risk (95% confidence limit) of death compared with medical therapy was 0.62 (0.28, 1.40) for surgery and 0.38 (0.24, 0.61) for transplantation in medium- to high-risk patients. For low-risk patients, the relative risks for death compared with medical therapy were 1.87 (0.63, 5.60) for surgery and 1.97 (0.79, 4.96) for transplantation.CONCLUSIONS:
Transplantation improved survival of medium- and high-risk patients compared with medical therapy. In the low-risk group, this was not evident. However, repeated assessment of risk is required because the hazard for death rises steadily after the third year in these patients.
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Base de dados:
MEDLINE
Assunto principal:
Cardiotônicos
/
Causas de Morte
/
Transplante de Coração
/
Insuficiência Cardíaca
/
Procedimentos Cirúrgicos Cardíacos
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article