RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis.
Genes Dev
; 19(17): 1974-9, 2005 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-16107613
ABSTRACT
The Rho proteins are Ras-related guanosine triphosphatases (GTPases) that function in cytoskeletal reorganization, cell migration, and stress fiber and focal adhesion formation. Overexpression of RhoC enhances the ability of melanoma cells to exit the blood and colonize the lungs. However, in vivo confirmation of RhoC's role in metastasis has awaited a RhoC-deficient mouse model. Here we report the generation of RhoC-deficient mice and show that RhoC is dispensable for embryonic and post-natal development. We demonstrate that loss of RhoC does not affect tumor development but decreases tumor cell motility and metastatic cell survival leading to a drastic inhibition of metastasis.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas rho de Ligação ao GTP
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Desenvolvimento Embrionário
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Metástase Neoplásica
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Neoplasias Experimentais
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article