T cell control of primary and latent cytomegalovirus infections in healthy subjects.
J Clin Immunol
; 25(5): 473-81, 2005 Sep.
Article
em En
| MEDLINE
| ID: mdl-16160916
ABSTRACT
The T cell repertoire required to control acute and latent CMV infection in otherwise healthy individuals was examined using both functional analysis and a wide range of MHC I tetramers. Both frequency and function of CMV specific T cells varied considerably between subjects, however, within subjects values remained stable over time. In total 16 +/- 3.5 CMV specific T cells/mul blood was detected, with obvious immunodominance between different CMV epitopes. Most subjects with latent infection showed low CMV specific T cell activity, whereas a subgroup (1/3) of individuals was high in either frequency or function of their CMV specific T cells. Patients with acute infection displayed high initial, but rapidly decreasing, numbers of CMV specific cells. In conclusion, a majority of healthy individuals readily seem to control latent CMV infection, whereas a subpopulation (1/3) of individuals uses a large proportion of their CD8+ T cell repertoire to control the infection.
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Base de dados:
MEDLINE
Assunto principal:
Subpopulações de Linfócitos T
/
Infecções por Citomegalovirus
/
Linfócitos T CD8-Positivos
/
Citomegalovirus
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article