Effect of carbonate substitution on the ultrastructural characteristics of hydroxyapatite implants.
J Mater Sci Mater Med
; 16(10): 899-907, 2005 Oct.
Article
em En
| MEDLINE
| ID: mdl-16167098
ABSTRACT
Carbonate ion substitution has been shown to be beneficial for increasing the amount of in vivo osseointegration to hydroxyapatite (HA). Nevertheless, mechanisms by which carbonate ions increase in vivo bioactivity are not fully understood. Sintered granules of HA and carbonate-substituted hydroxyapatite (CHA) were implanted for 6 and 12 weeks in an ovine model. Samples containing the bone-implant interface were prepared for transmission electron microscopy (TEM) and TEM was used to compare the in vivo reactivity of sintered granules of HA and CHA. The current findings demonstrated that CHA (1.2 and 2.05 wt.%) is more soluble than pure HA in vivo. More dissolution was observed from the CHA, at the bone-implant interface and within the implant, when compared to pure HA. A less crystalline phase was formed between the 2.05 wt.% CHA and bone at 12 weeks in vivo. Bone surrounding both the pure HA and 1.2 wt.% CHA was relatively disorganised at 12 weeks. In comparison, bone surrounding the 2.05 wt.% CHA was considerably more organised and in many regions collagen fibrils were present. Despite increased quality of bone surrounding 2.05 wt.% CHA, compared to 1.2 wt.% CHA, the amount of dissolution from both materials was similar.
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Base de dados:
MEDLINE
Assunto principal:
Carbonatos
/
Consolidação da Fratura
/
Durapatita
/
Substitutos Ósseos
/
Implantes Experimentais
/
Fraturas do Fêmur
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article