Congenital macrothrombocytopenias.
Blood Rev
; 20(2): 111-21, 2006 Mar.
Article
em En
| MEDLINE
| ID: mdl-16169642
ABSTRACT
Congenital macrothrombocytopenias comprise a heterogeneous group of rare disorders, characterized by abnormal giant platelets, thrombocytopenia and bleeding tendency with variable severity. Many of these disorders share common clinical and laboratory features, making accurate diagnosis difficult and patients are often misdiagnosed with and treated for idiopathic thrombocytopenic purpura. Recent progress in the elucidation of underlying defects and further developments of specific diagnostic techniques for several congenital macrothrombocytopenias have renewed our approach to the classification and the diagnosis of the disease. This review summarizes the current knowledge on the clinical and laboratory features of common congenital macrothrombocytopenias and discusses how that knowledge aids in making a proper diagnosis.
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Base de dados:
MEDLINE
Assunto principal:
Trombocitopenia
/
Plaquetas
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article