Syphilitic cerebral gumma with HIV infection.
Neurology
; 42(7): 1282-7, 1992 Jul.
Article
em En
| MEDLINE
| ID: mdl-1620334
ABSTRACT
We describe two human immunodeficiency virus (HIV)-infected patients with syphilitic cerebral gummas. Both patients presented with a seizure disorder associated with an isolated, peripherally located, contrast-enhancing lesion of the brain on CT. Cranial MRI performed on one patient revealed dural thickening in the region of the lesion. A brain biopsy in that patient revealed a lymphoplasmacytic infiltrate with extensive perivascular inflammation. Clinical manifestations, radiographic resolution of the lesions, and a decline in nontreponemal serologic tests for syphilis followed high-dose aqueous penicillin therapy in both patients. These patients illustrate that (1) cerebral mass lesions occurring with HIV infection may result from syphilis; (2) seizures may be the presenting manifestation of this form of neurosyphilis; and (3) high-dose, intravenous, aqueous penicillin is effective in treating these lesions.
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Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Neurossífilis
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article