[Determination of plasma and sputum substance P content in patients with chronic obstructive pulmonary disease or asthma].
Di Yi Jun Yi Da Xue Xue Bao
; 25(10): 1314-5, 2005 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-16234120
ABSTRACT
OBJECTIVE:
To investigate the role of substance P (SP) in chronic obstructive pulmonary disease (COPD) or asthma.METHOD:
Plasma and sputum samples were obtained from 26 COPD patients and 20 asthmatic patients as well as 12 healthy subjects for measurement of SP content.RESULTS:
Patients with COPD had significantly higher levels of SP in the plasma (7.9+/-2.6 pmol/L) and sputum (53.8+/-12.5 pmol/L) than the healthy subjects (3.6+/-1.7 pmol/L and 6.2+/-2.3 pmol/L, respectively, P<0.01). The asthmatic patients also had significantly higher SP levels (8.3+/-3.1 pmol/L and 46.9+/-10.2 pmol/L, respectively) than the healthy subjects, but there was no significant difference between COPD and asthmatic patients (P>0.05).CONCLUSION:
SP may be involved in the airway inflammation process in COPD and asthma.
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Base de dados:
MEDLINE
Assunto principal:
Asma
/
Escarro
/
Substância P
/
Pneumopatias Obstrutivas
Idioma:
Zh
Ano de publicação:
2005
Tipo de documento:
Article