Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one and its 3'-deoxysugar analogue as potential anti-hepatitis C virus agents.
Nucleosides Nucleotides Nucleic Acids
; 24(5-7): 957-60, 2005.
Article
em En
| MEDLINE
| ID: mdl-16248071
ABSTRACT
We recently discovered a novel compound, identified as N3, 5-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridinin-5-one, with anti-hepatitis C virus (HCV) activity in vitro. The structure was confirmed by chemical synthesis from 2-hydroxy-5-nitropyridine. It showed anti-HCV activity with EC50= 19.7 microM in replicon cells. Its 3'-deoxy sugar analogue was also synthesized, but was inactive against HCV in vitro.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Hepatite C
/
Hepacivirus
/
Nucleosídeos
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article