Novel function of TNF cytokines in regulating bone marrow B cell survival.
Cell Mol Immunol
; 1(6): 447-53, 2004 Dec.
Article
em En
| MEDLINE
| ID: mdl-16293214
ABSTRACT
Two newly identified tumor necrosis factor (TNF) family cytokines, B cell activation factor from the TNF family (BAFF) and a proliferation-inducing ligand (APRIL), have recently been shown to enhance the maturation and survival of peripheral B cells. However, whether BAFF and APRIL are expressed in the bone marrow (BM) microenvironment and if these two cytokines modulate early B cell development remain unclear. In the present study, we have detected the abundant expression of BAFF and APRIL transcripts in BM non-lymphoid cells. Low levels of BAFF and APRIL mRNA are also found in developing B cells. Furthermore, we have determined the expression patterns of BAFF receptors during B lymphopoiesis. In cultures, both recombinant BAFF and APRIL significantly promote the survival of precursor B cells whereas only BAFF can suppress apoptosis of immature B cells. These findings suggest that BAFF and APRIL, in addition to their well established role in regulating peripheral B cell growth, can modulate the survival of developing B cells in the BM.
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Base de dados:
MEDLINE
Assunto principal:
Células da Medula Óssea
/
Linfócitos B
/
Diferenciação Celular
/
Fator de Necrose Tumoral alfa
/
Proteínas de Membrana
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article