Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists.
Bioorg Med Chem Lett
; 16(4): 989-94, 2006 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-16297617
A novel series of histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine template displaying low CYP2D6 and CYP3A4 inhibitory profiles has been identified. Structural features responsible for the reduction of P450 activity, a typical liability of 4-substituted imidazoles, have been established.
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Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Receptores Histamínicos H3
/
Inibidores Enzimáticos
/
Inibidores das Enzimas do Citocromo P-450
/
Antagonistas dos Receptores Histamínicos
/
Imidazóis
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article