Preferential migration of effector CD8+ T cells into the interstitium of the normal lung.
J Clin Invest
; 115(12): 3473-83, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16308575
ABSTRACT
The respiratory tract is a primary site of infection and exposure to environmental antigens and an important site of memory T cell localization. We analyzed the migration and retention of naive and activated CD8+ T cells within the noninflamed lungs and quantitated the partitioning of adoptively transferred T cells between the pulmonary vascular and interstitial compartments. Activated but not naive T cells were retained within the lungs for a prolonged period. Effector CD8+ T cells preferentially egressed from the pulmonary vascular compartment into the noninflamed pulmonary interstitium. T cell retention within the lung vasculature was leukocyte function antigen-1 dependent, while the egress of effector T cells from the vascular to the interstitium functions through a pertussis toxin-sensitive (PTX-sensitive) mechanism driven in part by constitutive CC chemokine ligand 5 expression in the lungs. These results document a novel mechanism of adhesion receptor- and pulmonary chemokine-dependent regulation of the migration of activated CD8+ T cells into an important nonlymphoid peripheral site (i.e., the normal/noninflamed lung).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Movimento Celular
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Linfócitos T CD8-Positivos
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Pulmão
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article