Amylase: a disease activity index in multiple myeloma?
Leuk Lymphoma
; 47(1): 151-4, 2006 Jan.
Article
em En
| MEDLINE
| ID: mdl-16321841
ABSTRACT
This study reports a case of a patient with lambda-light chain multiple myeloma who developed a high hyperamylasaemia of the salivary type during the disease and soon afterwards died. Ectopic production of amylase by myeloma cells has been described in a few cases and demonstrated by tissue culture and immunohistochemical techniques. The common characteristics of these cases were salivary amylase isoenzyme increase, high tumor mass, extensive extra-medullary spread, extensive bone destruction and poor prognosis. In patients with amylase-producing multiple myeloma, the onset of hyperamylasaemia heralds a rapid disease progression; therefore, in these patients, a simple test such as serum amylase may represent a reliable disease activity index and provide an additional prognostic information.
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Base de dados:
MEDLINE
Assunto principal:
Amilases
/
Mieloma Múltiplo
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article