Renal tubular dysgenesis associated with in utero exposure to Nimuselide.
Pediatr Nephrol
; 21(2): 274-6, 2006 Feb.
Article
em En
| MEDLINE
| ID: mdl-16328538
ABSTRACT
Maternal ingestion of the selective cyclo-oxygenase-2 (COX-2) inhibitor Nimuselide has been reported to be associated with the development of oligohydramnios and neonatal renal failure in some cases. We report a case of neonatal renal failure associated with maternal ingestion of Nimuselide in the third trimester of pregnancy. The neonate presented with metabolic acidosis and non-oliguric renal failure on the second day of life. The renal histopathology showed evidence of renal tubular dysgenesis. The child continues to have elevated serum creatinine and hypertension at 10 months of age.
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Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
/
Sulfonamidas
/
Anormalidades Induzidas por Medicamentos
/
Inibidores de Ciclo-Oxigenase
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Insuficiência Renal
/
Túbulos Renais
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article